With VMware ESX, you can virtualize any environment, from the corporate data center to the branch office, with a compatibility list that includes more than 200 server and storage systems, and a broad range of supported guest operating systems, including Windows, Linux, Netware, and Solaris. And due to the VMware’s inherent Virtual Machine encapsulation each OS is isolated from others on the physical server. This means that yes you can run different OS flavors on a single physical server.